Potential API Contraindications
Prednisolone Phosphate
- Adverse Reactions:
- Secondary ocular infection
- Glaucoma
- Increased intraocular pressure
- Optic nerve damage
- Subcapsular posterior cataract
- Blurred vision
- Dysgeusia (altered taste)
- Eye irritation
- Eye pain
- Foreign body sensation of eye
- Headache
- Hypersensitivity reaction
- Pruritis (itching)
- Skin rash
- Transient burning
- Stinging of the eyes
- Urticaria (rash of round red welts or swelling)
- Visual Disturbance
- Contraindications:
- Cataracts
- Corneal thinning
- Glaucoma
- Immunosuppression
- Systemic Absorption
Moxifloxacin
- Adverse Reactions:
- Eye irritation
- Conjunctivitis
- Decreases visual acuity
- Eye discomfort or pain
- Pruritus
- Lacrimation
- Ocular hyperemia (dilation and redness of the conjunctival vessels)
- Subconjunctival hemorrhage (bright red patch appearing in the white of the eye)
- Xerophthalmia (abnormal dryness of the conjunctiva and cornea of the eye)
- Contraindications:
- Hypersensitivity to moxifloxacin or other quinolones in any component or other forms
Bromfenac
- Adverse Reactions:
- Anterior chamber inflammation
- Iritis (inflammation of the iris)
- Ocular hypertension
- Vitreous Opacity (seeing floaters on the eye)
- Eye pain
- Abnormal sensation in the eyes
- Conjunctival Hyperemia (dilation and redness of the conjunctival vessels)
- Eye irritation (burning/stinging)
- Eye pruritus
- Eye redness
- Contraindications:
- Allergic cross-reactivity to nonsteroidal anti-inflammatory drugs (NSAIDS)
Gatifloxacin
- Adverse Reactions:
- Conjunctival hemorrhage (red patch appearing in the white of the eye)
- Conjunctival irritation
- Conjunctivitis
- Decreased visual acuity
- Dry eye syndrome
- Eye discharge
- Eye irritation
- Eye pain and redness
- Eyelid edema (eyelid swelling)
- Blepharitis (inflammation of eyelid)
- Increased lacrimation
- Keratitis (inflammation of the cornea of the eye)
- Papillary conjunctivitis (allergic reaction of the eye)
- Small round bumps develop on the underside of the eyelid
- Blurred vision
- Contraindications:
- Hypersensitivity to Gatifloxacin or quinolones in any component or form
Dexamethasone
- Adverse Reactions: Implant or Injection
- Cataract (incidence increases in patients requiring a second injection)
- Conjunctival hemorrhage
- Corneal edema
- Increased intraocular pressure
- Iritis
- Anterior chamber inflammation
- Blepharitis
- Blepharoptosis (drooping of the upper eyelid)
- Blurred vision
- Conjunctival edema
- Conjunctival hyperemia
- Conjunctivitis
- Corneal erosion
- Cystoid macular edema
- Decreased visual acuity
- Eye pain
- Foreign body sensation
- Keratitis
- Ocular hypertension
- Ophthalmic inflammation
- Photophobia
- Retinal hole without detachment
- Secondary cataract
- Vitreous detachment
- Vitreous opacity
- Xerophthalmia (abnormal dryness of the conjunctiva and cornea of the eye)
- Adverse Reactions: solution or suspension
- Eye discomfort
- Eye irritation
- Abnormal sensation in the eyes (foreign body sensation of eye)
- Blurred vision
- Conjunctivitis
- Crusting of eyelid
- Dry eye syndrome
- Eye pruritis
- Increased lacrimation
- Keratitis
- Ocular hyperemia
- Photophobia
- Burning sensation
- Cataract
- Decreased visual acuity
- Eye perforation
- Glaucoma (with optic nerve damage)
- Inadvertent filtering bleb
- Stinging of the eyes
- Visual field defect
- Blepharoptosis (drooping of the upper eye lid)
- Corneal erosion
- Endophthalmitis (infection inside the eye)
- Eye pain
- Hypotony of eye (vitreous leakage from injection)
- Injury to the eye region
- Mydriasis (dilation of the pupil)
- Retinal detachment
- Contraindications: Implant or Injection
- Intracanalicular insert:
- Active corneal, conjunctival or canalicular infections including epithelial herpes simplex keratitis, vaccinia, varicella, mycobacterial infections and fungal diseases
- In patients with a posterior lens capsule that is torn or ruptured
- Intravitreal ocular implant:
- Hypersensitivity to dexamethasone or any component of the formulation
- Glaucoma with a cup to disc ratio of >0.8
- Active corneal, conjunctival or canalicular infections including epithelial herpes simplex keratitis, vaccinia, varicella, mycobacterial infections and fungal diseases
- In patients with a posterior lens capsule that is torn or ruptured
- Ophthalmic suspension, solution, ointment:
- Hypersensitivity to dexamethasone or any component of the formulation
- Active corneal, conjunctival or canalicular infections including epithelial herpes simplex keratitis, vaccinia, varicella, mycobacterial infections and fungal diseases
- In patients with a posterior lens capsule that is torn or ruptured
- Intracanalicular insert:
Tropicamide
- Adverse Reactions:
- Blurred vision
- Photophobia
- Stinging of eyes
- Superficial punctate keratitis
- Increased intraocular pressure
- Contraindications:
- Hypersensitivity to tropicamide or any component of the formulation
Phenylephrine
- Adverse Reactions:
- Burning sensation of eyes
- Eye irritation
- Miosis (excessive constriction of the pupil of the eye)
- Visual disturbance
- Vitreous opacity
- Contraindications:
- Hypertension and thyrotoxicosis in infants younger than 1 year
Timolol
- Adverse Reactions:
- Burning sensation of eyes
- Stinging of the eyes
- Blepharitis
- Blepharoptosis (drooping of the upper eye lid)
- Blurred vision
- Cataract
- Choroidal detachment following filtration surgery
- Conjunctival injection
- Conjunctivitis
- Cystoid macular edema
- Decreased corneal sensitivity
- Decreased visual acuity
- Diplopia (double vision)
- Eye discharge
- Eye pain
- Eye pruritus
- Foreign body sensation of the eye
- Hyperemia
- Keratitis
- Lacrimation
- Visual disturbance
- Xerophthalmia (abnormal dryness of the conjunctiva and cornea of the eye)
- Contraindications:
- Documented cross-reactivity for other ophthalmic beta-adrenergic blocking agents
Brimonidine
- Adverse Reactions:
- Burning
- Follicular conjunctivitis
- Visual disturbance
- Blepharitis
- Blepharoconjunctivitis (inflammation of the eye lid and conjunctiva)
- Blurred vision
- Cataract
- Conjunctival edema
- Conjunctival hemorrhage
- Conjunctivitis
- Decreased visual acuity
- Dry eye syndrome
- Epiphora (watery eye)
- Eye discharge
- Eye irritation
- Eyelid disease
- Eyelid edema
- Eye pain
- Keratitis
- Photophobia
- Sting of eyes
- Superficial punctate keratitis
- Visual field defect
- Vitreous detachment
- Vitreous opacity
- Contraindications:
- Hypersensitivity to Brimonidine
- Use in infants
- Concomitant use of MOA inhibitors
Dorzolamide
- Adverse Reactions:
- Burning sensation of eyes
- Eye discomfort
- Stinging of eyes
- Superficial punctate keratitis
- Blurred vision
- Conjunctivitis
- Eyelid irritation
- Eye redness
- Lacrimation
- Photophobia
- Xerophthalmia (abnormal dryness of the conjunctiva and cornea of the eye)
- Iridocyclitis (inflammation of the iris and the ciliary body)
- Crusting of the eyelid
- Epistaxis
- Myopia
- Ocular pain
- Contraindications:
- Hypersensitivity to Dorzolamide or any other form
Latanoprost
- Adverse Reactions:
- Eye Pain
- Stinging of the eyes
- Ocular Hyperemia
- Conjunctival Hyperemia
- Eye Discharge
- Increased eyelash length
- Increased eyelash thickness
- Punctuate keratitis
- Blurred vision
- Eye pruritis
- Burning sensation of the eyes
- Iris hyperpigmentation
- Decreased visual acuity
- Eyelid pain
- Lacrimation
- Crusting of eyelid
- Dry eye syndrome
- Photophobia
- Eyelid Edema
- Conjunctival edema
- Contraindications:
- Hypersensitivity to latanoprost
- Hypersensitivity to benzalkonium chloride (preservative)
Bimatoprost
- Adverse Reactions:
- Eye hyperemia (dilation and redness of the conjunctival vessels)
- Eye edema
- Eye hemorrhage
- Eye irritation
- Eye pain
- Eye pruritus (itching)
- Erythema of eyelid (Redness)
- Eyelids pruritus (itching)
- Growth of eyelashes
- Instillation site irritation
- Punctate keratitis
- Skin hyperpigmentation
- Vision blurred
- Visual acuity reduced
- Dry eye
- Contraindications:
- Bimatoprost is contraindicated in patients with hypersensitivity to bimatoprost or to any of the ingredients.
Atropine
- Adverse Reactions:
- Blurred Vision
- Decreased lacrimation
- Decreased visual acuity (reversible, healthy eye)
- Eye irritation
- Eye pain
- Eyelid edema
- Papillary conjunctivitis
- Photophobia
- Stinging of eyes
- Superficial Keratitis
- Contraindications:
- Hypersensitivity to Atropine or any form
- Primary Glaucoma or tendency toward angle-closure glaucoma (narrowing or closure of anterior chamber)
- Documentation of an allergic cross-sensitivity for anticholinergic medication
Ketorolac
- Adverse Reactions:
- Burning sensation of the eyes
- Stinging of the eyes
- Blurred vision
- Conjunctival hyperemia
- Corneal edema
- Corneal infiltrates
- Eye irritation or pain
- Eyelid edema
- Increased intraocular pressure
- Lacrimation
- Ocular edema
- Ocular hyperemia
- Superficial eye infection
- Superficial keratitis
- Swelling of the eye
- Corneal ulcer
- Dry eye syndrome
- Corneal erosion
- Corneal perforation
- Corneal thinning
- Contraindications:
- Hypersensitivity to ketorolac or any other form
- Documentation of a cross-sensitivity reaction to other NSAIDs
Reference:
- Lexi-Comp Online®, Lexi-drugs, Hudson, Ohio: Lexi-comp, Inc.; September 9th, 2021.